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Unlike most weight-loss drugs that act by suppressing appetite or altering metabolism, Adipotide uses a vascular-targeting mechanism:
It contains a targeting domain that binds to specific proteins (like prohibitin and annexin A2) found on the endothelial cells lining blood vessels that feed white fat.
Once bound, a pro-apoptotic domain triggers programmed cell death (apoptosis) in those blood vessels.
When the blood supply is cut off, the downstream fat cells lose nutrients and oxygen, leading to their death and eventual reduction in fat tissue.
This approach essentially “starves” the fat cells by destroying their vascular support.